Hyaluronic acid (HA; conjugate base hyaluronate), also called hyaluronan, is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues.
Introduction
Hyaluronic acid (HA; conjugate base hyaluronate), also called hyaluronan, is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. It is unique among glycosaminoglycans in that it is nonsulfated, forms in the plasma membrane instead of the Golgi apparatus, and can be very large, with its molecular weight often reaching the millions. One of the chief components of the extracellular matrix, hyaluronan contributes significantly to cell proliferation and migration, and may also be involved in the progression of some malignant tumors.The average 70 kg (154 lb) person has roughly 15 grams of hyaluronan in the body, one-third of which is turned over (degraded and synthesized) every day. Hyaluronic acid is also a component of the group A streptococcal extracellular capsule, and is believed to play a role in virulence.
Functions and Applications
1. Hyaluronic Acid could be used in eye surgery, such as corneal transplantation, cataract surgery, glaucoma surgery, and surgery to repair retinal detachment
2. Hyaluronic Acid can also be used to treat osteoarthritis of the knee. They are administered as a course of injections into the knee joint, which are believed to supplement the viscosity of the joint fluid, thereby lubricating the joint, cushioning the joint, and producing an analgesic effect.
3. Hyaluronic Acid has also been used in the synthesis of biological scaffolds for woundhealing applications. These scaffolds typically have proteins such as fibronectin attached to the Hyaluronic Acid to facilitate cell migration into the wound.
4. Hyaluronic Acid is also used in antiadhesive products, which are widely used in pelvic and abdominal surgery to prevent postoperative adhesions.
| Product name：Sodium hyaluronate | Grade：Food grade | |
| Batch No.：2020012256 Production Date：2020.01.09 | ||
| Total Quantity：2050kg Expiry Date 2022.01.08 | ||
| Item | Standard | Result |
| Appearance | White or almost white powder or granule | Complied |
| Glucuronic acid | ≥44.5% | 47.20% |
| Sodium hyaluronate | ≥92.0% | 97.70% |
| pH | 6.0～8.0 | 6.6 |
| Transmittance | T600nm≥99.0% | 99.70% |
| Loss on drying | ≤10.0% | 6.90% |
| Molecular weight | measured value | 1.15*106 |
| Intrinsic viscosity | measured value | 19.2dL/g |
| The bulk density | measured value | 0.30g/cm3 |
| The tap density | measured value | 0.44g/cm3 |
| Protein | ≤0.1% | 0.05% |
| Ash | ≤13.0% | <13.0% |
| Heavy metal (as Pb) | ≤10mg/kg | <10mg/kg |
| Arsenic | ≤2mg/kg | <2mg/kg |
| Bacteria counts | ≤100CFU/g | Complied |
| Molds & Yeasts | ≤50CFU/g | Complied |
| Staphylococcus aureus | Negative/g | Negative |
| Escherichia coli | Negative/g | Negative |
| Salmonella | Negative/g | Negative |
| Conclusion：Up to the Q/FCG 4.1.112-2017 standards | ||
| Product name： Sodium Hyaluronate | Batch No.： 2021011622 | |
| Total Quantity： 143.6kg | Specification：Cosmetic Grade | |
| Production Date：December 29th 2020 | Expiry Date：December 28th 2022 | |
| Item | Standard | Result |
| Appearance | White or almost white,very hygroscopic powder or fibrous aggregate | Complied |
| Solubility | Sparingly soluble or soluble in water,practically insoluble in acetone and in anhydrous ethanol | Complied |
| A.Infrared absorption spectrophotometry | Complied | |
| Identification | Bit gives reaction(a)of sodium | Complied |
| Sodium hyaluronate | >95% | 99.3% |
| Appearance of Solution | A600nmW | Complied |
| Nucleic Acids | A260nmW 0.5 | Complied |
| PH | 5.0-8.5 | 6.4 |
| Molecular weight | Measured value | 0.16M Da |
| Intrinsic viscosity | Measured value | 4.13dL/g |
| Protein | ≥0.1% | 0.04% |
| Loss on drying | ≤10.0% | 6.7% |
| Chlorides | ≤0.5% | Complied |
| Iron | ≤80ppm | <80ppm |
| TAMC | <100CFU/g | Complied |
| Staphylococcus aureus | Negative/g | Complied |
| Pseudomonas aeruginosa | Negative/g | Complied |
| Conclusion：Complied with EP9.0 | ||
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