Nisin 1414-45-5

Nisin is a polycyclic antibacterial peptide produced by the bacterium Lactococcus lactis that is used as a food preservative. It has 34 amino acid residues, including the uncommon amino acids

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Introduction

Nisin is a polycyclic antibacterial peptide produced by the bacterium Lactococcus lactis that is used as a food preservative. It has 34 amino acid residues, including the uncommon amino acids lanthionine (Lan), methyllanthionine (MeLan), didehydroalanine (Dha), and didehydroaminobutyric acid (Dhb). These unusual amino acids are introduced by posttranslational modification of the precursor peptide. In these reactions a ribosomally synthesized 57-mer is converted to the final peptide. The unsaturated amino acids originate from serine and threonine, and the enzyme-catalysed addition of cysteine residues to the didehydro amino acids result in the multiple thioether bridges.

Subtilin and epidermin are related to nisin. All are members of a class of molecules known as lantibiotics.

In the food industry, nisin is obtained from the culturing of L. lactis on natural substrates, such as milk or dextrose, and it is not chemically synthesized.

It was originally isolated in the late 1930s, and produced since the 1950s as Nisaplin from naturally occurring sources by Aplin and Barrett in laboratories in Beaminster in Dorset, and approved as an additive for food use in the USA in the late 1960s, although the Beaminster factory now is owned by DuPont.

Functions and Applications

1. Nisin can be used in a wide range of heat-processed foods

2. These include: fresh milk, processed cheese and other dairy products, pasteurized liquid eggs, processed meat, seafood, canned food, fruit drinks, plant protein drinks, baked products, instant food, beer, and wine

3. It can also be used as a preservative in gelatin processing, cosmetics, drugs and health products.

Expiration: two years in cool (0°C - 10°C., dry conditions, away from direct sunlight in original unopened packs.

Product Name	Food/Beverage/Cosmetics Natural Preservative Nisin/nisin e234 price
Appearance	white or a kind of white crystal powder
NISIN CONTENT	1125IU/mg
MOISTURE CONTENT	1.652
SODIUM CHLORIDE	85.2
Lead(Pb)/ (mg/kg)	MAX1
COUNT OF COLONY IN 1g	MAX 10
E.COLI IN 100g	MAX 30
SALMONELLAE	ABSENT in 25g

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